William B. Line, President of DOES, Inc., has 35 years of product development experience.


Bill is currently working on developing an insulin inhaler for diabetics to eliminate the use of injected insulin. Inhaled insulin, developed by Pfizer,  has been called the greatest improvement for diabetics since the invention of insulin in the 1920s. He previously helped develop a pulmonary drug delivery device to deliver small particles. He worked with Allegheny-Teledyne-Allvac and General Electric using statistical Design of Experiments (DOE) to develop a dry-powder metal alloy for use in a GE Aircraft engine. He used DOE to certify a copper alloy for use in high moisture environments for the Federal Metal Company. He recently completed a research project in Indonesia and another in Sweden, developing a fruit beverage.


He has designed tests for National Aeronautics and Space Administration (NASA) using third and fourth-order models to predict flight parameters from wind tunnel tests. These models were used to test the space shuttle. For NASA he developed other statistical methods to calibrate force moment balances. These methods reduced the amount of testing by 90% and improved the accuracy of calibrations. The savings to NASA are $500,000. per test. NASA patented this method that was developed by DOES staff.


Bill was a Reliability Test Engineer for Martin Company in developing the Patriot Surface-to-Air  missile used in the Persian Gulf war to shoot down Scud missiles. He helped develop the Sprint missile of the Nike-X Zeus defense system. He has consulted with Lockheed-Martin developing a system to predict and control flight parameters for the F-16 fighter plane. F-16 predictions were substantially improved, while reducing the amount of test data required and saving costs. He has Top Secret military clearance.


DOES Institute, founded and managed by Mr. Line, has worked directly with MIT, George Washington University, Dr. J.M. Juran and the Juran Institute, W. Edwards Deming and the Deming Institute, John Wiley & Sons books in developing and distributing quality improvement technology, CD-ROMs and software to organizations worldwide.


William B. Line has conducted statistical seminars in London, Honduras, Nicaragua, Winston-Salem and San Francisco for the education of industry, government, and academic personnel.  These seminars featured Dr. George Box, Dr. Ray Myers and other excellent speakers and emphasized the use of statistical methods for product improvement. He has taught statistical methods at Rollins University in Winter Park, Florida. For 25 years, he has taught many in-house training courses in statistics for RJ Reynolds Nabisco and KOBE Copper Company of Japan.


Mr. William B. Line is particularly proud of his 20-year working association with Dr. George E. P. Box, FRS, who developed Response Surface Methods, Evolutionary Operations, and Box-Jenkins forecasting. He has also worked with Dr. Norman Draper (author of the book - Applied Regression Analysis) in developing Higher-Order models for NASA. He worked for 25 years with Dr. Ray Myers, VPI to develop many new statistical test designs to reduce sample size and reduce test costs.


He has been an employee of the Martin-Marietta Company, Magnavox, and Senior Statistician for the R.J. Reynolds Nabisco Company. In his career, he has developed processes for , drugs, aircraft, apparel, candy, paper, metal, agriculture, tobacco, automobiles, and missile systems. 


He has BS and MS degrees from the University of Tennessee where he studied under Professor David S. Chambers. He majored in Mathematical Statistics, with emphasis on Experimental Design. He has been a member of Toastmasters International speakers club for 25 years.



Peter A. Parker (NASA LaRC), Michael Morton (RJ Reynolds), Dr. Norman R. Draper (University of Wisconsin, Madison, WI), William Line (DOES Institute), “A Single-Vector Force Calibration Method Featuring the Modern Design of Experiments,” presented at the American Institute of Aeronautics and Astronautics, 38th Aerospace Sciences Meeting & Exhibit, 10 January 2000.


William B. Line, Matt Zugowski, “Certification of Federal Metal Alloy C89833 Using a Designed Experiment (DOE),” 24 September 2002; to be presented to the American Society for Testing Materials (ASTM),     October 2003.


William B. Line, Principal Investigator, “Force Balance Calibration Models For Aircraft Testing"  (NASA Order No L – 12406), 6 September 2000. (This work saved NASA millions of dollars per year, thus NASA patented it). Mr. Line’s name is on the patent.


William B. Line, Principal Investigator, “Force Balance Calibration Models For Aircraft Testing” (NASA Order No L – 11326), 27 July 27 2000.


William B. Line, Principal Investigator, “Fourth Order Model Terms For Aircraft Testing  (NASA Order

No L –69266D), 23 September 1999.


William B. Line, Principal Investigator, “Third Order Model Terms for Aircraft Testing” (NASA Order

No L-7910), 15 September 1998.


Ivan Neas, G. W. Brown, J.P. Dickerson, R.M. Henderson, W.B. James, and W.B. Line,  Evaluation of Once-Over Low-Profile Harvested Tobacco: Part I. 

Processing and Leaf Analysis,” Tobacco Science 22 (1978):59-53.


Ivan Neas, G. W. Brown, J.P. Dickerson, R.M. Henderson, W.B. James, W.B. Line, and H. C. Threatt, Jr., “Evaluation of Once-Over Low-Profile Harvested Tobacco: Part II.  Smoke Chemistry and Smoking Panel Evaluation,” Tobacco Science, 22 (1978): 67-70.


William B. Line, “How To Sell Management On Using Response Surface Methods,” paper presented to the American Society for Quality Control (ASQC) Chemical Division, Charlotte, NC, October 1977.